| Identification | More | [Name]
Benproperine phosphate | [CAS]
19428-14-9 | [Synonyms]
1-[2-(2-benzylphenoxy)-1-methylethyl]piperidine phosphate
BENPROPERINE PHOSPHATE
BENPROPERINE PHOSPHATE CP2000
1-(2-Benzylphenoxy)-2-piperidinopropane phosphate
1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine monophosphate
ASA 158-5
Blascorid
Piperidine, 1-[1-methyl-2-[(a-phenyl-o-tolyl)oxy]ethyl]-, phosphate (1:1) (8CI)
Piperidine, 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-, phosphate (1:1)
Flaveric | [EINECS(EC#)]
243-050-0 | [Molecular Formula]
C21H30NO5P | [MDL Number]
MFCD01700461 | [Molecular Weight]
407.44 | [MOL File]
19428-14-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
150-152° | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C21H27NO.H3O4P/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19;1-5(2,3)4/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3;(H3,1,2,3,4) | [InChIKey]
MCVUURBOSHQXMK-UHFFFAOYSA-N | [SMILES]
C1(C=CC=CC=1OCC(C)N1CCCCC1)CC1=CC=CC=C1.P(=O)(O)(O)O | [CAS DataBase Reference]
19428-14-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
An antitussive. | [in vivo]
Benproperine phosphate (50, 100?mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth[1].
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Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1].
| Animal Model: | Female BALB/c nude mice of 6-week-old with AsPC-1 cells[1] | | Dosage: | 50, 100?mg/kg | | Administration: | Oral gavage; 5?days per week for 4?weeks | | Result: | Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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