| Identification | Back Directory | [Name]
FMK 9a | [CAS]
1955550-51-2 | [Synonyms]
FMK 9a
FMK-9A; FMK9A
1-Naphthalenecarboxamide, N-[(1S)-2-[(3-fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]- | [Molecular Formula]
C23H21FN2O3 | [MOL File]
1955550-51-2.mol | [Molecular Weight]
392.42 |
| Chemical Properties | Back Directory | [Boiling point ]
724.6±60.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: 100 mg/mL (254.83 mM) | [form ]
Solid | [pka]
12.82±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. | [in vivo]
FMK 9a shows moderate solubility (LYSA: 41 μg/mL) and high human and mouse liver microsome clearances of 13.9 and 70 mL/kg per minute[1]. | [storage]
Store at -20°C | [References]
[1] Qiu Z, et al. Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett. 2016 Jun 25;7(8):802-6. DOI:10.1021/acsmedchemlett.6b00208 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|