| Identification | Back Directory | [Name]
MPEG12-NH2 | [CAS]
1977493-48-3 | [Synonyms]
m-PEG13-amine
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaheptatriacontan-1-amine | [Molecular Formula]
C25H53NO12 | [MDL Number]
MFCD11041151 | [MOL File]
1977493-48-3.mol | [Molecular Weight]
559.69 |
| Chemical Properties | Back Directory | [Boiling point ]
583.6±45.0 °C(Predicted) | [density ]
1.073±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light, stored under nitrogen | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C25H53NO12/c1-27-4-5-29-8-9-31-12-13-33-16-17-35-20-21-37-24-25-38-23-22-36-19-18-34-15-14-32-11-10-30-7-6-28-3-2-26/h2-26H2,1H3 | [InChIKey]
MSKSQCLPULZWNO-UHFFFAOYSA-N | [SMILES]
C(N)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC |
| Hazard Information | Back Directory | [Description]
m-PEG12-amine is a monodisperse PEG linker containing an amino group, It is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. | [IC 50]
PEGs; Non-cleavable Linker | [References]
[1] Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259. DOI:10.1021/acs.bioconjchem.8b00906
[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1. |
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