| Identification | Back Directory | [Name]
2-Morpholinopyrimidin-4-ol | [CAS]
19810-79-8 | [Synonyms]
2-Morpholinopyrimidin-4-ol
2-Morpholin-4-yl-pyrimidin-4-ol
2-MorpholinopyriMidin-4(3H)-one
2-Morpholino-4(3H)-pyrimidinone
2-morpholin-4-yl-1H-pyrimidin-6-one
2-(4-Morpholinyl)-4(3h)-pyrimidinone
4(3H)-Pyrimidinone, 2-(4-morpholinyl)-
2-Morpholinopyrimidin-4-ol ISO 9001：2015 REACH | [Molecular Formula]
C8H11N3O2 | [MDL Number]
MFCD00234443 | [MOL File]
19810-79-8.mol | [Molecular Weight]
181.19 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-morpholino-4-hydroxypyrimidine from 2-methylthio-4-pyrimidinone (4.0 g, 0.0281 mol) and morpholine (3.05 g, 0.035 mol): 2-methylthio-4-pyrimidinone was mixed with morpholine, heated to 145°C and maintained for 2 hours. After completion of the reaction, it was cooled to room temperature. White needle-like crystals (2.0 g) were obtained by ethanol crystallization. Subsequently, a second batch of crystals of about 0.50 g was formed in a total yield of 49%. The product was detected by mass spectrometry showing M + H = 181.1. 1H NMR (CDCl3) data were as follows: δ 12.1 (broad peak, 1H), 7.85 (double peak, 1H), 5.79 (double peak, 1H), and 3.75 (multiple peaks, 8H). | [References]
[1] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 49 |
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| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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