| Identification | More | [Name]
4-Hydroxypyrimidine | [CAS]
51953-17-4 | [Synonyms]
4(1H)-PYRIMIDINONE
4(3H)-PYRIMIDINONE
4(3H)-PYRIMIDONE
4(6)-HYDROXYPYRIMIDINE
4-HYDROXYPYRIMIDINE
4-PYRIMIDINOL
4-PYRIMIDINONE
4-PYRIMIDONE
3H-pyrimidin-4-one
4(3H)-PYRIMIDONE, 98+%
4(3H)-Pyrimidinone (9CI)
4-HYDROXYPYRIMIDINE 98% | [EINECS(EC#)]
224-932-4 | [Molecular Formula]
C4H4N2O | [MDL Number]
MFCD00167178 | [Molecular Weight]
96.09 | [MOL File]
51953-17-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow powder | [Melting point ]
166-169 °C(lit.)
| [Boiling point ]
179.58°C (rough estimate) | [density ]
1.2604 (rough estimate) | [refractive index ]
1.4610 (estimate) | [storage temp. ]
0-6°C | [form ]
Powder | [pka]
pK1:1.85(＋1);pK2:8.59(0) (25°C) | [color ]
White to slightly yellow | [Water Solubility ]
270.3g/L(20 ºC) | [Detection Methods]
HPLC | [BRN ]
106975 | [InChI]
InChI=1S/C4H4N2O/c7-4-1-2-5-3-6-4/h1-3H,(H,5,6,7) | [InChIKey]
DNCYBUMDUBHIJZ-UHFFFAOYSA-N | [SMILES]
C1(=O)N=CNC=C1 | [CAS DataBase Reference]
51953-17-4(CAS DataBase Reference) | [Storage Precautions]
Store under inert gas |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UW7350100
| [TSCA ]
Yes | [HS Code ]
29339900 |
| Questions And Answer | Back Directory | [Description]
Pyrimidone(4-Hydroxypyrimidine) is the name given to either of two heterocyclic compounds with the formula C4H4N2O: 2-pyrimidone and 4-pyrimidone. The compounds can also be called 2-hydroxypyrimidine or 4-hydroxypyrimidine respectively, based on a substituted pyrimidine, or 1, 3-diazine, ring. 4-pyrimidinone is an important bioactive molecule with various biological activities such as anti-virus, anti-tumor, induction of interferon production and immune regulation. |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly yellow powder | [Uses]
4(3H)-pyrimidinone heterocyclic compounds and their pharmaceutically usable salts can be used to treat and/or prevent SHP2-mediated conditions, particularly in cancer clinical drug research. Furthermore, based on a series of studies on 4(3H)-pyrimidinones and their derivatives (such as 4-Hydroxypyrimidine), some substances have been found to act as modulators of the TRPV4 receptor, exhibiting promising properties in the treatment of various diseases and syndromes, especially in the treatment of inflammatory, painful, and urinary disorders and dysregulation. | [Hazard]
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. | [Enzyme inhibitor]
This hygroscopic pyrimidine, also known as 4-hydroxypyrimidine and 4- pyrimidinol (FW = 96.09 g/mol), inhibits both hypoxanthine(guanine) and xanthine phosphoribosyltransferases. |
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