| Identification | Back Directory | [Name]
Paliperidone Palmitate | [CAS]
199739-10-1 | [Synonyms]
RO 92670
Invega Sustenna
Paliperidone Palmitate
Paliperidone Palmitate-d31
Paliperidone Palmitate [USAN]
9-Hydroxyrisperidone palmitate
Paliperidone Palmitate USP/EP/BP
Paliperidone Palmitate Benzisoxazole Impurity
Paliperidone Impurity 39 (Paliperidone Palmitate)
3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl palmitate
(9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)et
hyl)-2-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyriMi
din-9-yl hexadecanoate
Hexadecanoic acid 3-[2-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester
Hexadecanoic acid 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester
Paliperidone palmitateQ: What is
Paliperidone palmitate Q: What is the CAS Number of
Paliperidone palmitate Q: What is the storage condition of
Paliperidone palmitate Q: What are the applications of
Paliperidone palmitate | [EINECS(EC#)]
225-799-5 | [Molecular Formula]
C39H57FN4O4 | [MDL Number]
MFCD24386477 | [MOL File]
199739-10-1.mol | [Molecular Weight]
664.893 |
| Chemical Properties | Back Directory | [Melting point ]
110-115°C | [Boiling point ]
736.3±70.0 °C(Predicted) | [density ]
1.19 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated), Methanol (Slightly) | [form ]
Solid | [pka]
8.07±0.10(Predicted) | [color ]
Off-White to Light Beige | [InChIKey]
VOMKSBFLAZZBOW-UHFFFAOYSA-N | [SMILES]
C(OC1C2N(CCC1)C(=O)C(CCN1CCC(C3C4=C(ON=3)C=C(F)C=C4)CC1)=C(C)N=2)(=O)CCCCCCCCCCCCCCC |
| Hazard Information | Back Directory | [Description]
Paliperidone palmitate is an atypical long acting antipsychotics，which
can fast onset in acute phase and continuously improve the symptoms in
maintenance phase． It has the solid efficacy and convenient
ad[1]ministration，which offer a new option for schizophrenia treatment
and will help patients to adhere the treatment and prevent relapse． As
the sole long acting antipsychotics with monthly injection，it was
approved by CFDA in 2011 and indicated for the acute and maintenance
treatment of schizophrenia． | [Uses]
Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.
| [Definition]
ChEBI: 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate is a fatty acid ester obtained by the formal condensation of the carboxy group of hexadecanoic acid with the hydroxy group of 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. It is a member of 1,2-benzoxazoles, a heteroarylpiperidine, an organofluorine compound, a pyridopyrimidine and a fatty acid ester. | [Side effects]
The review of the literature also underlined that paliperidone palmitate
is well tolerated, compared with placebo. Frequency and severity of
side-effects such as extrapyramidal symptoms, hyperprolactinemia and
weight gain, was similar or less than those found in treatment with
other atypical antipsychotics, including long-acting ones. | [Synthesis]
Aseptic air-flow mill was used to control the crushing pressure of 3~5bar, and the sterile paliperidone palmitate was crushed to the effective particle size of 2~15μm. Weighed 12g of sodium carboxymethyl cellulose, placed in about 500ml of injectabl |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Moltt Biocem Co., Ltd.
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+86-21-38682181 15900741819 |
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www.chemicalbook.com/ShowSupplierProductsList15856/0_EN.htm |
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