| Identification | Back Directory | [Name]
cyclopenin | [CAS]
20007-87-8 | [Synonyms]
NSC114538
NSC604989
NSC-604989
NSC-114538
cyclopenin
NSC 114538
NSC 604989
Spiro[3H-1,4-benzodiazepine-3,2'-oxirane]-2,5(1H,4H)-dione, 4-methyl-3'-phenyl-, (2'R,3'S)-rel-(-)- | [Molecular Formula]
C17H14N2O3 | [MOL File]
20007-87-8.mol | [Molecular Weight]
294.31 |
| Chemical Properties | Back Directory | [Melting point ]
183-184 °C | [Boiling point ]
572.5±50.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
12.92±0.40(Predicted) | [biological source]
plant | [Water Solubility ]
water: slightly soluble |
| Hazard Information | Back Directory | [Description]
Cyclopenin is an inhibitor of acetylcholinesterase (AChE; IC50 = 2.04 μM for human recombinant AChE) that is produced by Penicillium. It exhibits greater than 2,000-fold selectivity over recombinant equine butyrylcholinesterase with an IC50 value greater than 4,080 μM. Cyclopenin also has antibacterial activity against E. coli and M. pyogenes. | [Uses]
(-)-Cyclopenin ((-)-Cyclopenine) is the enantiomer of Cyclopenin. Cyclopenin is a selective acetylcholinesterase (AChE) inhibitor with the IC50 of 2.04 μM[1]. | [Definition]
ChEBI:(-)-cyclopenine is an epoxide. | [storage]
Store at -20°C | [References]
[1] F Kuno, et al. Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation. J Antibiot (Tokyo). 1996 Aug;49(8):748-51. DOI:10.7164/antibiotics.49.748 |
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