| Identification | More | [Name]
ETHANOLAMINE HYDROCHLORIDE | [CAS]
2002-24-6 | [Synonyms]
2-AMINOETHANOL HYDROCHLORIDE
2-HYDROXYETHYLAMINE HYDROCHLORIDE
2-HYDROXYETHYLAMMONIUM CHLORIDE
ETHANOLAMINE HCL
ETHANOLAMINE HYDROCHLORIDE
ETHANOLAMMONIUM CHLORIDE
MONOETHANOLAMINE HCL
MONOETHANOLAMINE HYDROCHLORIDE
2-amino-ethanohydrochloride
beta-aminoethanolhydrochloride
colaminehydrochloride
Ethanol,2-amino-,hydrochloride
ethanolaminechloride
meahydrochloride
ETHANOLAMINE HYDROCHLORIDE, 98+%
ETHANOLAMINE HYDROCHLORIDE, 99+%
ETHANOL-13C2-AMINE.HCL 99%
2-AminoethanolHCl=2-HydroxyethylamineHCl
Hydroxyethylamine hydrochloride
2-aminoethanol-13c2hydrochloride | [EINECS(EC#)]
217-900-6 | [Molecular Formula]
C2H8ClNO | [MDL Number]
MFCD00012892 | [Molecular Weight]
97.54 | [MOL File]
2002-24-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White or slightly beige agglomerating crystals | [Melting point ]
82-84 °C(lit.) | [density ]
1.07g/cm3 at 20—25°C
1.12g/cm3 at 20—25°C | [storage temp. ]
Store at RT. | [solubility ]
DMSO (Slightly, Heated) | [form ]
Agglomerating Crystals | [color ]
White or slightly beige | [Specific Gravity]
1.146 | [Odor]
Odorless | [PH]
9—10 | [pka]
9.5(at 25℃) | [Water Solubility ]
almost transparency | [Sensitive ]
Hygroscopic | [Merck ]
14,3727 | [BRN ]
3542892 | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
BUFFERING | [InChI]
1S/C2H7NO.ClH/c3-1-2-4;/h4H,1-3H2;1H | [InChIKey]
PMUNIMVZCACZBB-UHFFFAOYSA-N | [SMILES]
NCCO.[H]Cl | [LogP]
-1.308 (est) | [CAS DataBase Reference]
2002-24-6(CAS DataBase Reference) | [EPA Substance Registry System]
Ethanol, 2-amino-, hydrochloride (2002-24-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
1
| [RTECS ]
KJ6370000
| [F ]
3-10 | [TSCA ]
Yes | [HS Code ]
29221100 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White or slightly beige agglomerating crystals | [Uses]
Ethanolamine hydrochloride has been used:
- in overnight incubation of the tips to attach primary amine groups at the tip surface
- in the preparation of DMEM (dulbecco′s modified eagle′s medium)/F-12 media to culture human epidermal growth factor receptor 2 (HER2) cells derived from MMTV-HER2 transgenic mouse mammary tumors
- to administer the cultures to study its effect on the endogenous phosphatidyl ethanolamine pool and autophagy process
| [Biochem/physiol Actions]
Ethanolamine hydrochloride is utilized as a carbon and nitrogen source by bacteria that differs phylogenetically. It exists as phosphotidylethanolamine in the bacterial and mammalian cell membrane. Ethanolamine-ammonia lyase is responsible for the degradation of ethanolamine into acetaldehyde and ammonia. Ethanolamine is known to positively support lipid accumulation in photosynthetic organism model. | [Synthesis]
General procedure for the synthesis of ethanolamine hydrochloride from 2-aminoethanol:
Reagents and reaction conditions: 36% concentrated hydrochloric acid, room temperature.
Operating steps:
1. 15.0 g of 2-aminoethanol was weighed and added to three reaction flasks.
2. 27.0 g of 36% concentrated hydrochloric acid was added dropwise at a constant rate through a dropping funnel under stirring conditions, and the reaction temperature was controlled to be no more than 40 °C. 3.
3. after completion of the dropwise addition, the reaction mixture was continued to be stirred for 20 minutes until the pH was about 2 and the reaction was terminated.
4. remove water from the reaction system by concentration under reduced pressure until a very small amount of water remains.
5. A small amount of toluene was added and the residual water was further removed by azeotropic distillation.
6. The reaction mixture was rapidly cooled to give 23.7 g of a slightly light brown solid product, ethanolamine hydrochloride (M-07), in 99% yield. | [Purification Methods]
Recrystallise the salt from EtOH. It is deliquescent; store it dry. [Beilstein 4 IV 1406.] | [References]
[1] Bulletin des Societes Chimiques Belges, 1984, vol. 93, # 10, p. 903 - 912
[2] Patent: CN105585607, 2016, A. Location in patent: Paragraph 0107; 0108; 0109; 0110
[3] Green Chemistry, 2016, vol. 18, # 9, p. 2834 - 2842
[4] Green Chemistry, 2017, vol. 19, # 13, p. 3152 - 3163 |
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