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2002381-25-9

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2002381-25-9 Structure

2002381-25-9 Structure
IdentificationBack Directory
[Name]

APS-2-79
[CAS]

2002381-25-9
[Synonyms]

6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine
4-Quinazolinamine, 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)-
[Molecular Formula]

C23H21N3O3
[MOL File]

2002381-25-9.mol
[Molecular Weight]

387.43
Chemical PropertiesBack Directory
[Boiling point ]

528.6±50.0 °C(Predicted)
[density ]

1.246±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

5.58±0.30(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[HS Code ]

2922500090
Hazard InformationBack Directory
[Uses]

APS-2-79 is a modulator of KSR-dependent MAPK signaling, antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation as well as the activation of KSR-bound MEK (mitogen-activated protein kinase).
[IC 50]

KSR2: 120 nM (IC50); MEK1
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