| Identification | More | [Name]
2-Piperidinoethylchloride hydrochloride | [CAS]
2008-75-5 | [Synonyms]
1-(2-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE
1-(2-CHLOROETHYL)PIPERIDINE MONOHYDROCHLORIDE
2-(1-PIPERIDINO)ETHYL CHLORIDE HYDROCHLORIDE
2-CHLOROETHYLPIPERIDINE HCL
2-CHLOROETHYLPIPERIDINE HYDROCHLORIDE
2-PIPERIDINOETHYL CHLORIDE HYDROCHLORIDE
N-(2-CHLOROETHYL)PIPERIDINE HCL
N-(2-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE
N-(2-CHLOROETHYL)-PIPERIDINIUM CHLORIDE
N-(B-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE
N-CHLOROETHYL PIPERIDINE HYDROCHLORIDE
N-PIPERIDINOETHYL CHLORIDE HYDROCHLORIDE
PIPEC
PIPERIDINOETHYL CHLORIDE HYDROCHLORIDE
1-(2-chloroethyl)-piperidinhydrochloride
beta-chloroethylpiperidinehydrochloride
2-(N-Piperidino)ethyl chloride hydrochloride
1-(2-chloroethyl)piperidinium chloride
2-ChloroethylpiperidineHcl98%
2-Chloroethylpiperidine Hcl 98% | [EINECS(EC#)]
217-920-5 | [Molecular Formula]
C7H15Cl2N | [MDL Number]
MFCD00012837 | [Molecular Weight]
184.11 | [MOL File]
2008-75-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to beige crystals | [Melting point ]
230-232 °C(lit.)
| [Boiling point ]
196 °C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Powder or Crystals | [color ]
White to pale yellow to beige | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [Usage]
N-(2-Chloroethyl)piperidine hydrochloride (PIPEC) is used as intermediate for the syntheses of pharmaceuticals (e.g. fenpiverinium bromide, cloperastine and pitofenone). Product Data Sheet | [BRN ]
3910268 | [InChI]
InChI=1S/C7H14ClN.ClH/c8-4-7-9-5-2-1-3-6-9;/h1-7H2;1H | [InChIKey]
VFLQQZCRHPIGJU-UHFFFAOYSA-N | [SMILES]
N1(CCCl)CCCCC1.Cl | [CAS DataBase Reference]
2008-75-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H300-H314 | [Precautionary statements ]
P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
T+,Xi | [Risk Statements ]
R28:Very Toxic if swallowed.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 2928 6.1/PG 2
| [WGK Germany ]
2
| [RTECS ]
TM6482500
| [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29333999 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Oral
Skin Corr. 1B | [Toxicity]
mouse,LD50,intraperitoneal,93mg/kg (93mg/kg),BEHAVIORAL: ATAXIA,Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948. |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to beige crystals | [Uses]
1-(2-Chloroethyl)piperidine hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. fenpiverinium bromide, cloperastine and pitofenone).
| [Synthesis]
The general procedure for the synthesis of 1-(2-chloroethyl)piperidine hydrochloride using N-hydroxyethylpiperidine as starting material was as follows: N-hydroxyethylpiperidine (5 mL) was dissolved in chloroform (12.5 mL). Thionyl chloride (3.4 mL) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was slowly heated to reflux and the reflux reaction was maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give a large crystalline precipitate. Finally, the product was purified by ethanol recrystallization to give 5.88 g of 1-(2-chloroethyl)piperidine hydrochloride in 85% yield. | [References]
[1] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0048; 0049
[2] Patent: US2006/223855, 2006, A1. Location in patent: Page/Page column 160-161
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679 |
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