| Chemical Properties | Back Directory | [Boiling point ]
1219.3±65.0 °C(Predicted) | [density ]
1.275±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol : 50 mg/mL (48.23 mM) | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 4 nM for Brd4BD2. | [IC 50]
VHL; BRD4 BD2: 4 nM (Kd) | [storage]
Store at -20°C | [References]
[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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