| Identification | Back Directory | [Name]
4-Piperidinecarboxamide, 1-[3-[8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-2,3,6,7-tetrahydro-3-methyl-2,6-dioxo-1H-purin-1-yl]propyl]-N-phenyl- | [CAS]
2010927-65-6 | [Synonyms]
DPP-4/GPR119 modulator 2
4-Piperidinecarboxamide, 1-[3-[8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-2,3,6,7-tetrahydro-3-methyl-2,6-dioxo-1H-purin-1-yl]propyl]-N-phenyl- | [Molecular Formula]
C30H40N8O3 | [MOL File]
2010927-65-6.mol | [Molecular Weight]
560.69 |
| Hazard Information | Back Directory | [Uses]
DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 μM for DPP-IV and an EC50 of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research[1]. DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
DPP-4 | [References]
[1] Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017. DOI:10.1016/j.ejmech.2019.112017 |
|
|