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2014384-91-7

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2014384-91-7 Structure

2014384-91-7 Structure
IdentificationBack Directory
[Name]

Nangibotide
[CAS]

2014384-91-7
[Synonyms]

Nangibotide
L-Methioninamide, L-leucyl-L-glutaminyl-L-α-glutamyl-L-α-glutamyl-L-α-aspartyl-L-alanylglycyl-L-α-glutamyl-L-tyrosylglycyl-L-cysteinyl-
[Molecular Formula]

C54H82N14O22S2
[MOL File]

2014384-91-7.mol
[Molecular Weight]

1343.44
Chemical PropertiesBack Directory
[Boiling point ]

1902.1±65.0 °C(Predicted)
[density ]

1.397±0.06 g/cm3(Predicted)
[pka]

4.19±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Nangibotide is a TREM-1 receptor inhibitor that can modulate innate immune response. Nangibotide can reduce systemic and in situ inflammatory reaction in rodent models of myocardial ischaemia‐reperfusion[1].
[References]

[1] Cuvier V, et, al. A first-in-man safety and pharmacokinetics study of nangibotide, a new modulator of innate immune response through TREM-1 receptor inhibition. Br J Clin Pharmacol. 2018 Oct;84(10):2270-2279. DOI:10.1111/bcp.13668
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