| Identification | Back Directory | [Name]
BETA-[2-([2-(8-AZASPIRO[4.5]DEC-8-YLCARBONYL)-4,6-DIMETHYLPHENYL]AMINO)-2-OXOETHYL]-(R)-1-NAPHTHALENEPROPANOIC ACID | [CAS]
201605-51-8 | [Synonyms]
CR 2945
ITRIGLUMIDE
BETA-[2-([2-(8-AZASPIRO[4.5]DEC-8-YLCARBONYL)-4,6-DIMETHYLPHENYL]AMINO)-2-OXOETHYL]-(R)-1-NAPHTHALENEPROPANOIC ACID
1-Naphthalenepropanoic acid, β-[2-[[2-(8-azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylphenyl]amino]-2-oxoethyl]-, (βR)-
β-[2-[(2-(8-Azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylphenyl)amino]-2-oxoethyl]-(R)-1-naphthalenepropanoic acid sodium-potassium salt
Itriglumide, β-[2-[(2-(8-Azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylphenyl)amino]-2-oxoethyl]-(R)-1-naphthalenepropanoic acid sodium-potassium salt | [Molecular Formula]
C33H38N2O4 | [MDL Number]
MFCD02684407 | [MOL File]
201605-51-8.mol | [Molecular Weight]
526.67 |
| Hazard Information | Back Directory | [Uses]
Itriglumide (CR 2945) is an anthranilic acid derivative. Itriglumide is a potent and selective CCKB receptor antagonist, with an IC50 of 2.3 nM. Itriglumide antagonizes the response to gastrin in a dose-dependent manner with an IC50 of 5.9 nM. Itriglumide shows antisecretory and antiulcer activity[1]. | [IC 50]
CCKBR: 2.3 nM (IC50) | [References]
[1] Makovec F, et al. Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist. Eur J Pharmacol. 1999 Mar 12;369(1):81-90. DOI:10.1016/s0014-2999(99)00069-2 |
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SIGMA-RBI
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800 736 3690 (Orders) |
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www.sigma-aldrich.com |
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