| Identification | Back Directory | [Name]
Azido-PEG4-(CH2)3OH | [CAS]
2028281-87-8 | [Synonyms]
Azido-PEG4-(CH2)3OH
N3-PEG4-CH2CH2CH2OH | [Molecular Formula]
C11H23N3O5 | [MDL Number]
MFCD30458014 | [MOL File]
2028281-87-8.mol | [Molecular Weight]
277.317 |
| Hazard Information | Back Directory | [Description]
Azido-PEG4-(CH2)3OH is a PEG compound with three carbon chain between PEG fragemnt and OH group, it contain a 4 PEG units. The azide group can react with alkyne, BCN, DBCO via Click Chemistry | [Uses]
Azido-PEG4-(CH2)3OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-(CH2)3OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
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