| Identification | Back Directory | [Name]
Azido-PEG3-(CH2)3OH | [CAS]
1807512-36-2 | [Synonyms]
Azido-PEG3-C3-OH
Azido-PEG3-(CH2)3OH
N3-PEG3-CH2CH2CH2OH
α-Azido-ω-propanl poly(ethylene glycol) | [Molecular Formula]
C9H19N3O4 | [MDL Number]
MFCD28950754 | [MOL File]
1807512-36-2.mol | [Molecular Weight]
233.265 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C9H19N3O4/c10-12-11-2-5-15-7-9-16-8-6-14-4-1-3-13/h13H,1-9H2 | [InChIKey]
UUSDGPCVMBHTRJ-UHFFFAOYSA-N | [SMILES]
C(COCCN=[N+]=[N-])OCCOCCCO |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-(CH2)3OH is a PEG linker with three carbon chain between PEG fragemnt and OH group, The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Azido-PEG3-C3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-C3-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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