| Identification | Back Directory | [Name]
UT-155 | [CAS]
2031161-35-8 | [Synonyms]
UT-155
UT-155,Inhibitor,UT155,inhibit,Androgen Receptor,UT 155
1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)-
1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)- | [Molecular Formula]
C20H15F4N3O2 | [MDL Number]
MFCD31746902 | [MOL File]
2031161-35-8.mol | [Molecular Weight]
405.35 |
| Chemical Properties | Back Directory | [Boiling point ]
613.6±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);246.7(Max Conc. mM) | [form ]
Solid | [pka]
12.74±0.29(Predicted) | [color ]
White to off-white | [InChI]
InChI=1/C20H15F4N3O2/c1-19(29,11-27-7-6-12-8-14(21)3-5-17(12)27)18(28)26-15-4-2-13(10-25)16(9-15)20(22,23)24/h2-9,29H,11H2,1H3,(H,26,28)/t19-/s3 | [InChIKey]
CFSAYQVTXBMPRF-DETXXQSHNA-N | [SMILES]
C(N1C=CC2=CC(F)=CC=C12)[C@@](O)(C)C(=O)NC1C=CC(C#N)=C(C(F)(F)F)C=1 |&1:11,r| |
| Hazard Information | Back Directory | [Uses]
UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD. | [in vivo]
Consistent with the anti-proliferative effects in vitro, UT-155 significantly inhibits the growth of 22RV1 xenograft by 53%, while, as expected, enzalutamide has no effect on the growth of the 22RV1 tumors. Tumor weights and PSA and the expression of AR and AR-SV are significantly lower in UT-155-treated animals[1]. | [storage]
Store at -20°C | [References]
[1] Ponnusamy S, et al. Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer. Cancer Res. 2017 Nov 15;77(22):6282-6298. DOI:10.1158/0008-5472.CAN-17-0976 |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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