| Hazard Information | Back Directory | [Description]
BC-1485 is a first-in-class inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1 ), which disrupts FIEL1-directed PIAS4 ubiquitination. | [Uses]
BC-1485 is a small molecule inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1). BC-1485 protects PIAS4 from ubiquitin-mediated degradation. BC-1485 decreases α-SMA, BAL and CXCL1. BC-1485 ameliorates fibrotic lung injury in murine models[1][2]. | [IC 50]
CXCR1 | [References]
[1] Lear T, et al. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30;213(6):1029-46. DOI:10.1084/jem.20151229
[2] Lear T, et al. Therapeutic targets in fibrotic pathways. Cytokine. 2016 Dec;88:193-195. DOI:10.1016/j.cyto.2016.09.008 |
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