| Identification | Back Directory | [Name]
JNJ-61432059 | [CAS]
2035814-50-5 | [Synonyms]
JNJ-61432059
iGluR,JNJ 61432059,Inhibitor,Ionotropic glutamate receptors,JNJ-61432059,JNJ61432059,inhibit
2H-Indol-2-one, 5-[2-(4-fluorophenyl)-7-(4-hydroxy-1-piperidinyl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydro- | [Molecular Formula]
C25H22FN5O2 | [MDL Number]
MFCD32062672 | [MOL File]
2035814-50-5.mol | [Molecular Weight]
443.47 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (112.75 mM) | [form ]
Solid | [pka]
13.60±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1]. | [storage]
Store at -20°C | [References]
[1] Savall BM, et al. Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272. DOI:10.1021/acsmedchemlett.8b00599 |
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