| Identification | Back Directory | [Name]
LSD1-IN-6 | [CAS]
2035912-43-5 | [Synonyms]
LSD1-IN-6
LSD1IN6,LSD1 IN 6,LSD-1-IN-6
Benzenecarboximidamide, 4-[(1E)-2-(2-bromo-4,5-dihydroxyphenyl)ethenyl]-N'-hydroxy-, [C(Z)]- | [Molecular Formula]
C15H13BrN2O3 | [MDL Number]
MFCD30741842 | [MOL File]
2035912-43-5.mol | [Molecular Weight]
349.18 |
| Chemical Properties | Back Directory | [Melting point ]
184-185 °C | [Boiling point ]
530.4±60.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
6.87±0.69(Predicted) |
| Hazard Information | Back Directory | [Uses]
LSD1-IN-6 (Compound 4m) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM. LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1[1]. | [IC 50]
KDM1/LSD1 | [storage]
Store at -20°C | [References]
[1] Duan YC, et al. Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. Eur J Med Chem. 2017 Jan 27;126:246-258. DOI:10.1016/j.ejmech.2016.11.035 |
|
|