| Identification | More | [Name]
2-Chloro-6-fluorophenol | [CAS]
2040-90-6 | [Synonyms]
2-CHLORO-6-FLUOROPHENOL
Chlorofluorophenol3
2-Chloro-6-fluorophenol, 97+%
6-CHLORO-2-FLUORO PHENOL | [EINECS(EC#)]
433-890-8 | [Molecular Formula]
C6H4ClFO | [MDL Number]
MFCD01631574 | [Molecular Weight]
146.55 | [MOL File]
2040-90-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
62-65 °C (lit.) | [Boiling point ]
160.6±20.0 °C(Predicted) | [density ]
1.408±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
7.23±0.10(Predicted) | [color ]
White to Light yellow | [BRN ]
1936441 | [InChI]
InChI=1S/C6H4ClFO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H | [InChIKey]
QIAQIYQASAWZPP-UHFFFAOYSA-N | [SMILES]
C1(O)=C(F)C=CC=C1Cl | [CAS DataBase Reference]
2040-90-6(CAS DataBase Reference) | [EPA Substance Registry System]
Phenol, 2-chloro-6-fluoro- (2040-90-6) |
| Safety Data | Back Directory | [Symbol(GHS) ]
   
GHS05,GHS07,GHS08,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H302-H314-H340-H361f-H411 | [Precautionary statements ]
P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1759 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [REACH Registrations]
Inactive | [HazardClass ]
8 | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [PackingGroup ]
II | [HS Code ]
29081990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Dam. 1
Muta. 1B
Repr. 2
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
2-Chloro-6-fluorophenol serves as a precursor for aryl benzoates via acylation with substituted benzoyl chlorides under basic conditions or in dichloromethane with triethylamine[1]. It reacts with sodium chlorite hydrate in sulfuric acid to prepare quinones[2]. | [References]
[1]
Mohammed, Y. H. I., Alghamdi, S., Almasmoum, H. A., Shntaif, A. H., Suhail, N., Rajab, B. S., Alhag, S. K., Hafiz, M. N., Jawad, M. M., Senan, A. M. (2026). Design, synthesis, and anticancer activity of phenoxyacetohydrazide derivatives in burkitt lymphoma. Scientific Reports, 16(1). https://doi.org/10.1038/s41598-026-52968-9
[2]
Magnier, E., Diter, P., Blazejewski, J.-C. (2008). The trifluoromethoxy group as a fluorine twin in the Diels–Alder reactions of halogenated quinones. Tetrahedron Letters, 49(31), 4575–4578. https://doi.org/10.1016/j.tetlet.2008.05.104 |
|
|