| Chemical Properties | Back Directory | [Boiling point ]
736.8±70.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Solid | [pka]
9.66±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1]. | [Biological Activity]
BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].
BI-6901 (intraperitoneal injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1]. | [in vivo]
BI-6901 (intraperitoneal?injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1]. | Animal Model: | Balb-C mice with a DNFB model of contact hypersensitivity. | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal?injection | | Result: | Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice. |
| [storage]
Store at -20°C | [References]
[1]. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. |
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