| Identification | Back Directory | [Name]
1H-Pyrano[3,2-a]phenazine-2-carbonitrile, 3,5-diamino-1-(3,4-dichlorophenyl)- | [CAS]
2043660-80-4 | [Synonyms]
CPUL1
1H-Pyrano[3,2-a]phenazine-2-carbonitrile, 3,5-diamino-1-(3,4-dichlorophenyl)- | [Molecular Formula]
C22H13Cl2N5O | [MOL File]
2043660-80-4.mol | [Molecular Weight]
434.28 |
| Hazard Information | Back Directory | [Uses]
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic α-Lipoic Acid (HY-N0492) or Dithiodipropionic Dithiodipropionic acid (HY-W014395) is more effective[1]. | [References]
[1] Ding Q, et al. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production. Mol Biol Rep. 2022 Sep;49(9):8835-8845. DOI:10.1007/s11033-022-07733-2 |
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