| Identification | More | [Name]
1-Bromo-3,5-dimethoxybenzene | [CAS]
20469-65-2 | [Synonyms]
1-BROMO-3 5-DIMETHOXYBENZENE 97
3，5-Dimethoxybromobenzene
1-Bromo-3,5-dimethoxybenzene | [EINECS(EC#)]
695-168-0 | [Molecular Formula]
C8H9BrO2 | [MDL Number]
MFCD06200685 | [Molecular Weight]
217.06 | [MOL File]
20469-65-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
At 0°C, a small solution of 7.4 g (107 mmol) sodium nitrate in 15 mL of distilled water was added to a solution of 10.0 g (65.3 mmol) 3,5-dimethoxyaniline in 30 mL of 48% hydrobromic acid until the presence of the diazonium salt was observed with starch-potassium iodide paper. Simultaneously, a mixture of 5.2 g (36 mmol) cuprous bromide in 5.2 mL of 48% hydrobromic acid was heated to boiling in another flask. The resulting diazonium salt solution was added in small amounts to the cuprous bromide-hydrobromic acid solution, maintaining its boiling point. After the addition was complete, the total reaction mixture was stirred and heated for another 30 minutes. The resulting crude product was purified by steam distillation, yielding 7.84 g of 1-bromo-3,5-dimethoxybenzene as a white solid, in a yield of 55.8%, with a melting point of 63-64°C. 
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| Chemical Properties | Back Directory | [Melting point ]
62-66 °C (lit.) | [Boiling point ]
246.0±20.0 °C(Predicted) | [density ]
1.412±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in methanol. | [form ]
Crystals or Crystalline Powder | [color ]
White to yellow | [InChI]
InChI=1S/C8H9BrO2/c1-10-7-3-6(9)4-8(5-7)11-2/h3-5H,1-2H3 | [InChIKey]
KRWRFIMBWRVMKE-UHFFFAOYSA-N | [SMILES]
C1(Br)=CC(OC)=CC(OC)=C1 | [CAS DataBase Reference]
20469-65-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow crystals | [Uses]
1-Bromo-3,5-dimethoxybenzene may be used to synthesize the following:
- bis-[di-(3,5-dimethoxyphenyl)methylcyclopentadienyl]titanium(IV)dichloride,{η5 - C5H4-CH-[C6H4-(OCH3)2]2)2TiCl2 which can be used as an anti-cancer drug and is obtained via a multistep reaction process
- 5-bromo-benzene-1,3-diol via demethylation with boron tribromide(BBr3)
- 1-bromo-3,5-dimethoxy-2-nitrobenzene via nitration reaction
| [Uses]
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions. | [General Description]
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Aemon Chemical
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| Telephone: |
0086-755-86198205 |
| Website: |
www.aemonchem.com |
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