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204974-93-6

204974-93-6 Structure

204974-93-6 Structure
IdentificationBack Directory
[Name]

4-((3-((4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)methyl)benzyl)oxy)benzimidamide
[CAS]

204974-93-6
[Synonyms]

BIIL-260)
BIIL260 (BIIL 260
4-((3-((4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)methyl)benzyl)oxy)benzimidamide
Benzenecarboximidamide, 4-[[3-[[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxy]methyl]phenyl]methoxy]-
[Molecular Formula]

C30H30N2O3
[MOL File]

204974-93-6.mol
[Molecular Weight]

466.57
Chemical PropertiesBack Directory
[Boiling point ]

654.2±65.0 °C(Predicted)
[density ]

1.14±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

powder
[pka]

10.59±0.10(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Uses]

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with the Ki value of 1.7 nM[1].
[Biological Activity]

BIIL260 is a selective and potent leukotriene B4 (BLT1) receptor antagonist with a Ki value of 1.8 nM in human U937 cells. BIIL260 was used found to act as an inverse agoniststabilizing the inactive state of BLT1.
[References]

[1] Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. PMID:11259574
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