| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, 3-amino-N-[(2S)-2-hydroxypropyl]-5-[[4-(trifluoromethoxy)phenyl]sulfonyl]- | [CAS]
2055015-61-5 | [Synonyms]
GLPG2451
GLPG2451,GLPG-2451
2-Pyridinecarboxamide, 3-amino-N-[(2S)-2-hydroxypropyl]-5-[[4-(trifluoromethoxy)phenyl]sulfonyl]- | [Molecular Formula]
C16H16F3N3O5S | [MDL Number]
MFCD32067928 | [MOL File]
2055015-61-5.mol | [Molecular Weight]
419.38 |
| Chemical Properties | Back Directory | [Boiling point ]
628.8±55.0 °C(Predicted) | [density ]
1.471±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 270 mg/mL (643.81 mM) | [form ]
Solid | [pka]
12.45±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1]. | [References]
[1] Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221. DOI:10.3389/fphar.2018.01221 |
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