| Identification | Back Directory | [Name]
Bromoacetamido-PEG8-t-butyl ester | [CAS]
2055041-16-0 | [Synonyms]
Bromoacetamido-PEG8-Boc
Bromoacetamido-PEG8-t-butyl ester
4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 1,1-dimethylethyl ester | [Molecular Formula]
C25H48BrNO11 | [MDL Number]
MFCD29918248 | [MOL File]
2055041-16-0.mol | [Molecular Weight]
618.55 |
| Chemical Properties | Back Directory | [Boiling point ]
657.2±55.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
13.20±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG8-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromoacetamido-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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