| Identification | Back Directory | [Name]
Bromoacetamido-PEG3-t-Butyl Ester | [CAS]
1807537-33-2 | [Synonyms]
BrCH2CONH-PEG3-COOtBu
Bromoacetamido-PEG3-C2-Boc
Bromoacetamido-PEG3-t-Butyl Ester
tert-Butyl 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate | [Molecular Formula]
C15H28BrNO6 | [MDL Number]
MFCD28505521 | [MOL File]
1807537-33-2.mol | [Molecular Weight]
398.29 |
| Chemical Properties | Back Directory | [Boiling point ]
507.6±50.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
13.20±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG3-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|