| Identification | Back Directory | [Name]
N-Boc-N-bis(PEG3-NHS ester) | [CAS]
2055042-31-2 | [Synonyms]
N-Boc-N-bis(PEG3-NHS ester)
4,7,10,16,19,22-Hexaoxa-13-azapentacosanedioic acid, 13-[(1,1-dimethylethoxy)carbonyl]-, 1,25-bis(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C31H49N3O16 | [MDL Number]
MFCD29912756 | [MOL File]
2055042-31-2.mol | [Molecular Weight]
719.731 |
| Chemical Properties | Back Directory | [Boiling point ]
751.6±70.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
-1.61±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
N-Boc-N-bis(PEG3-NHS ester) is a branched molecule with a Boc protected amino group and two terminal NHS esters. . The NHS esters can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Boc can be deprotected under acidic conditions | [Uses]
N-Boc-N-bis(PEG3-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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