| Identification | Back Directory | [Name]
PC-Biotin-PEG4-NHS carbonate | [CAS]
2055198-03-1 | [Synonyms]
PC-Biotin-PEG4-NHS carbonate | [Molecular Formula]
C35H50N6O14S | [MDL Number]
MFCD29079395 | [MOL File]
2055198-03-1.mol | [Molecular Weight]
810.87 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
13.90±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
PC-Biotin-PEG4-NHS carbonate is a unique amine reactive, photocleavable biotin reagent that is useful for introducing a biotin moiety to amine-containing biomolecules. The NHS carbonate portion of this compound reacts specifically with primary amine groups on the target molecule(s) to form a carbamate linkage. Captured biomolecules can be efficiently photoreleased using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2). | [Uses]
PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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