| Identification | Back Directory | [Name]
A-9758 | [CAS]
2055271-22-0 | [Synonyms]
A-9758
A9758,A 9758
4-Piperidinecarboxylic acid, 1-[2,4-dichloro-3-[[1,4-dimethyl-6-(trifluoromethyl)-1H-indol-2-yl]methyl]benzoyl]- | [Molecular Formula]
C25H23Cl2F3N2O3 | [MDL Number]
MFCD32197234 | [MOL File]
2055271-22-0.mol | [Molecular Weight]
527.36 |
| Chemical Properties | Back Directory | [Boiling point ]
691.3±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.36±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation[1]. | [IC 50]
RORγt: 5 nM (IC50); IL-17A; IL-23 | [storage]
Store at -20°C | [References]
[1] Gauld S, et al. Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt. J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046. DOI:10.1124/jpet.119.258046 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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