| Hazard Information | Back Directory | [Description]
TCO-PEG24-NHS Ester is a monodisperse PEG linker containing a TCO moiety and an NHS ester. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. TCO enable click chemistry with tetrazine | [Uses]
TCO-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG24-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|