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2055896-98-3

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2055896-98-3 Structure

2055896-98-3 Structure
IdentificationBack Directory
[Name]

MC-Val-Cit-PAB-duocarmycin
[CAS]

2055896-98-3
[Synonyms]

MC-Val-Cit-PAB-duocarmycin
[Molecular Formula]

C54H65ClN9O9+
[MDL Number]

MFCD34574974
[MOL File]

2055896-98-3.mol
[Molecular Weight]

1019.62
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
[IC 50]

Duocarmycins
[References]

[1] Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. DOI:10.1038/nchem.2635
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