| Identification | Back Directory | [Name]
XMU-MP-1 | [CAS]
2061980-01-4 | [Synonyms]
CS-2590
XMU-MP-1
PubChem ID: 121499143
4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide
4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]- | [Molecular Formula]
C17H16N6O3S2 | [MDL Number]
MFCD30377214 | [MOL File]
2061980-01-4.mol | [Molecular Weight]
416.48 |
| Chemical Properties | Back Directory | [Boiling point ]
714.8±70.0 °C(Predicted) | [density ]
1.523±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
≥41.6 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH | [form ]
powder | [pka]
9.77±0.12(Predicted) | [color ]
white to beige | [InChI]
InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21) | [InChIKey]
YRDHKIFCGOZTGD-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=C(NC2=NC=C3C(=N2)N(C)C2C=CSC=2C(=O)N3C)C=C1 |
| Hazard Information | Back Directory | [Description]
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively).1 It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury. | [Uses]
XMU-?MP-?1 an MST1/2 inhibitor. | [storage]
Store at -20°C | [References]
1. fuqin fan, zhixiang he, lu-lu kong, et al. pharmacological targeting of kinases mst1 and mst2 augments tissue repair and regeneration. science translational medicine 17 aug 2016: vol. 8, issue 352, pp. 352ra108. |
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