| Identification | More | [Name]
5-BROMO-2-IODO-M-XYLENE | [CAS]
206559-43-5 | [Synonyms]
5-BROMO-2-IODO-1,3-XYLENE
5-BROMO-2-IODO-3-XYLENE
5-BROMO-2-IODO-M-XYLENE | [EINECS(EC#)]
606-594-3 | [Molecular Formula]
C8H8BrI | [MDL Number]
MFCD03094656 | [Molecular Weight]
310.96 | [MOL File]
206559-43-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2903998090 |
| Hazard Information | Back Directory | [Synthesis]
The diazotization reaction was carried out using sodium nitrite and hydrochloric acid in acetonitrile solvent at 0 °C using 4-bromo-2,6-dimethylaniline as starting material. Subsequently, the diazonium group was converted to iodine by addition of potassium iodide to afford the target product 5-bromo-2-iodo-1,3-xylene in 96% yield. The synthesis was described with reference to known literature (NonPatentDocument 2). | [References]
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 16, p. 7202 - 7217
[2] Patent: JP5959171, 2016, B2. Location in patent: Paragraph 0258-0260
[3] Bulletin of the Chemical Society of Japan, 2001, vol. 74, # 11, p. 2207 - 2218
[4] Patent: WO2009/74314, 2009, A1. Location in patent: Page/Page column 168-169 |
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