| Identification | Back Directory | [Name]
Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)- | [CAS]
2070009-55-9 | [Synonyms]
Benzamide, N-[(1S)-2-[4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl]-1-[[[2-(dimethylamino)acetyl]amino]methyl]ethyl]-3-chloro-4-(1-methylethoxy)- | [Molecular Formula]
C29H36ClN5O4 | [MOL File]
2070009-55-9.mol | [Molecular Weight]
554.08 |
| Chemical Properties | Back Directory | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 32 mg/mL (57.75 mM) | [form ]
Solid | [pka]
13.32±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent. | [in vivo]
PF-2771 (100 mg/kg, every day i.p.) potently inhibits CENP-E motor function, and causes tumor regression in SCID mice bearing AA1077 mammary tumors[1]. | [IC 50]
CENP-E: 16.1 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Kung PP, et al. Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer. Mol Cancer Ther. 2014 Aug;13(8):2104-15. DOI:10.1158/1535-7163.MCT-14-0083-T |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|