| Identification | Back Directory | [Name]
IFN alpha-IFNAR-IN-1 (hydrochloride) | [CAS]
2070014-98-9 | [Synonyms]
IFN alpha-IFR-IN-1 hydrochloride
IFN-α-IFNAR-IN-1 (hydrochloride)
IFN alpha-IFNAR-IN-1 (hydrochloride)
IFN alpha-IFNAR inhibitor 1 hydrochloride | [Molecular Formula]
C??H??ClNS | [MDL Number]
MFCD29472229 | [MOL File]
2070014-98-9.mol | [Molecular Weight]
315.86 |
| Hazard Information | Back Directory | [Uses]
IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1]. | [References]
[1] Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. DOI:10.1002/anie.201105901 |
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