| Identification | Back Directory | [Name]
WEHI-539 HCl | [CAS]
2070018-33-4 | [Synonyms]
WEHI-539 HCl
WEHI539 HYDROCHLORIDE ;WEHI 539 HYDROCHLORIDE
5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5~{H}-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid | [Molecular Formula]
C31H30ClN5O3S2 | [MDL Number]
MFCD26960962 | [MOL File]
2070018-33-4.mol | [Molecular Weight]
620.18 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≥28.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | [form ]
solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM. | [Biological Activity]
wehi-539 hydrochloride is a small-molecule inhibitor of bcl xl with ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xl inhibitor with high affinity. it interacted with the binding groove of bcl-xl with kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome c and caspase-3 processing. in bcl-xl overexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539 cannot kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xl and mcl-1. [1]. | [IC 50]
Bcl-xL: 1.1 nM (IC50) | [storage]
Store at -20°C | [References]
[1]. lessene g, czabotar pe, sleebs be, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397. |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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