| Identification | Back Directory | [Name]
Methyl 2-amino-4,5-difluorobenzoate | [CAS]
207346-42-7 | [Synonyms]
Methyl 2-amino-4,5-d
Methyl 2-amino-4,5-difluo
ETHYL2-AMINO-4,5-DIFLUOROBENZOATE
Methyl 2-amino-4,5-difluorobenzoate
Methyl2-amino-4,5-difluorobenzoate,98%
Methyl 2-amino-4,5-difluorobenzoate USP/EP/BP
Benzoic acid, 2-amino-4,5-difluoro-, methyl ester
Benzoic acid, 2-amino-4,5-difluoro-, methyl ester (9CI)
2-aMino-4,5-difluoro-benzoic acid,Methyl ester, Methyl 4,5-difluoroanthranilate, 2-aMino-4,5-difluoro-benzoic acid, Methyl ester, Methyl 2-aMino-4,5-difluorobenzoate | [Molecular Formula]
C8H7F2NO2 | [MDL Number]
MFCD09264511 | [MOL File]
207346-42-7.mol | [Molecular Weight]
187.14 |
| Chemical Properties | Back Directory | [Boiling point ]
274.1±40.0 °C(Predicted) | [density ]
1.355±0.06 g/cm3(Predicted) | [storage temp. ]
Room temperature. | [form ]
Solid | [pka]
1.33±0.10(Predicted) | [color ]
White | [InChI]
InChI=1S/C8H7F2NO2/c1-13-8(12)4-2-5(9)6(10)3-7(4)11/h2-3H,11H2,1H3 | [InChIKey]
VIAQNTRKUPBQKR-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC(F)=C(F)C=C1N |
| Hazard Information | Back Directory | [Synthesis]
Step 3: Methyl 4,5-difluoro-2-nitrobenzoate (23.0 g, 106 mmol) was dissolved in EtOAc (200 mL) and 10% Pd/C catalyst (wet, 50% water content, 6.0 g) was added. The reaction mixture was placed in a Parr hydrogenation reactor and the reaction was oscillated at 50 PSI hydrogen pressure for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, and the filtrate was concentrated by rotary evaporation to afford methyl 2-amino-4,5-difluorobenzoate (1c) as a colorless solid with a yield of 19.0 g in 96% yield. | [References]
[1] Patent: WO2008/36843, 2008, A2. Location in patent: Page/Page column 33 |
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