| Identification | Back Directory | [Name]
Hydroxy-PEG5-acid | [CAS]
2079768-50-4 | [Synonyms]
HO-PEG5-CH2CH2COOH
Hydroxy-PEG5-propionic acid
Propanoic acid, 3-[(14-hydroxy-3,6,9,12-tetraoxatetradec-1-yl)oxy]- | [Molecular Formula]
C13H26O8 | [MDL Number]
MFCD31380407 | [MOL File]
2079768-50-4.mol | [Molecular Weight]
310.34 |
| Chemical Properties | Back Directory | [Boiling point ]
455.7±45.0 °C(Predicted) | [density ]
1.162±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG5-acid is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Uses]
Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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