| Identification | Back Directory | [Name]
befiradol | [CAS]
208110-64-9 | [Synonyms]
F 13640
NLX 112)
befiradol
Unii-rat9oha1yh
Befiradol
(F 13640
1-(3-Chloro-4-fluorobenzoyl)-4-fluoro-N-[(5-methyl-2-pyridinyl)methyl]-4-piperidinemethanamine
(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[(5-methyl-2-pyridinyl)methyl]amino]methyl]-1-piperidinyl]- | [Molecular Formula]
C20H22ClF2N3O | [MDL Number]
MFCD04113187 | [MOL File]
208110-64-9.mol | [Molecular Weight]
393.86 |
| Chemical Properties | Back Directory | [Boiling point ]
536.9±50.0 °C(Predicted) | [density ]
1.30 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.01±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Befiradol (NLX-112) is a selective 5-HT1A receptor agonist. | [Biological Activity]
NLX-112 (also known as befiradol or F13640) is a highly selective 5-HT1A receptor full agonist with >1000-fold selectivity compared to other types of receptors. It has been investigated for the treatment of Parkinsonμs disease patients who exhibit L-DOPA-induced dyskinesia | [IC 50]
5-HT1A Receptor | [storage]
Store at -20°C | [References]
[1] Lladó-Pelfort L, et al. In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat. Psychopharmacology (Berl). 2012 May;221(2):261-72. DOI:10.1007/s00213-011-2569-9 |
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