| Identification | More | [Name]
3-Chloro-4-fluorobenzylamine | [CAS]
72235-56-4 | [Synonyms]
3-CHLORO-4-FLUOROBENZYLAMINE
RARECHEM AL BW 0299
3-CHLORO-4-FLUOROBENZENEMETHANAMINE
3-Chloro-4-fluorobenzylamine 97%
3-Chloro-4-fluorobenzylamine97%
(3-Chloro-4-fluorophenyl)methanamine
1-(3-chloro-4-fluorophenyl)methanamine | [EINECS(EC#)]
670-917-4 | [Molecular Formula]
C7H7ClFN | [MDL Number]
MFCD00042507 | [Molecular Weight]
159.59 | [MOL File]
72235-56-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
262-263 °C(Solv: N,N-dimethylformamide (68-12-2)) | [Boiling point ]
111 °C | [density ]
1.27g/ml | [refractive index ]
1.536 | [Fp ]
104-105°C/15mm | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
clear liquid | [pka]
8.72±0.10(Predicted) | [color ]
Colorless to Light orange to Yellow | [Sensitive ]
Air Sensitive | [BRN ]
8614630 | [CAS DataBase Reference]
72235-56-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2735 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29214200 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow liquid | [Uses]
3-Chloro-4-fluorobenzylamine is a pharmaceutical intermediate used in the preparation of benzimidazole-based SOS1 activators and HIV-1 integrase inhibitors [1-2]. | [References]
[1]
Hodges, T. R., Abbott, J. R., Little, A. J., Sarkar, D., Salovich, J. M., Howes, J. E., Akan, D. T., Sai, J., Arnold, A. L., Browning, C., Burns, M. C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J. A., Scharn, D., Stadtmueller, H., Rossanese, O. W., Phan, J., … Fesik, S. W. (2018). Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Journal of Medicinal Chemistry, 61(19), 8875–8894. https://doi.org/10.1021/acs.jmedchem.8b01108
[2] Zhao, X. Z., Smith, S. J., Métifiot, M., Johnson, B. C., Marchand, C., Pommier, Y., Hughes, S. H., Burke, T. R., Jr (2014). Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants. Journal of medicinal chemistry, 57(4), 1573–1582. https://doi.org/10.1021/jm401902n
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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