| Identification | Back Directory | [Name]
SUC-TYR-VAL-ALA-ASP-PNA | [CAS]
208264-84-0 | [Synonyms]
SUC-YVAD-PNA
SUC-TYR-VAL-ALA-ASP-PNA
Suc-Tyr-Val-Ala-Asp-p-nitroanilide
Caspase-1 and Caspase-4 Chromogenic Substrate
L-α-Asparagine,N-(3-carboxy-1-oxopropyl)-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
N-(3-Carboxy-1-oxopropyl)-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-alpha-asparagine
CASPASE-1 AND CASPASE-4 CHROMOGENIC SUBSTRATE;SUC-TYR-VAL-ALA-ASP-P-NITROANILIDE;SUC-YVAD-PNA
L-α-Asparagine, N-(3-carboxy-1-oxopropyl)-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)- (9CI)
(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-(3-carboxypropanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid | [Molecular Formula]
C31H38N6O12 | [MDL Number]
MFCD01318836 | [MOL File]
208264-84-0.mol | [Molecular Weight]
686.67 |
| Chemical Properties | Back Directory | [Boiling point ]
1186.9±65.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
Acetic Acid (50%): soluble | [form ]
A solid | [pka]
4.04±0.10(Predicted) | [Sequence]
{Suc}-Tyr-Val-Ala-Asp-pNA |
| Hazard Information | Back Directory | [Uses]
Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases)[1]. | [References]
[1] N Margolin, et al. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J Biol Chem. 1997 Mar 14;272(11):7223-8. DOI:10.1074/jbc.272.11.7223 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|