| Identification | Back Directory | [Name]
Rp-8-bromo-Cyclic GMPS (sodium salt) | [CAS]
208445-06-1 | [Synonyms]
Rp-8-bromo-Cyclic GMPS (sodium salt)
Rp-8-Br-cGMPS sodium salt >=98% (HPLC) | [Molecular Formula]
C10H10BrN5NaO6PS | [MDL Number]
MFCD04037242 | [MOL File]
208445-06-1.mol | [Molecular Weight]
462.149 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤3.6mg/ml in ethanol;12.5mg/ml in DMSO;16.7mg/ml in dimethyl formamide | [form ]
crystalline solid | [color ]
white to beige | [InChIKey]
CHTSSROWUAICIL-GMKUFTCMSA-M | [SMILES]
O=C1C2=C(N([C@@H]3O[C@H](CO[P@@](O4)([O-])=S)[C@@H]4[C@H]3O)C(Br)=N2)N=C(N)N1.[Na+] |
| Hazard Information | Back Directory | [Uses]
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell[1][2]. | [Biological Activity]
rp-8-bromo-cyclic gmps is a cgmp-dependent protein kinase (cgk) inhibitor.cgmp is considered as an important regulator of vascular smooth muscle tone. several smooth muscle relaxants including nitrogen oxide-containing vasodilators), endothelial-derived relaxing factors, and atrial natriuretic peptides can stimulate cgmp production in vascular smooth muscle. in addition, many of these agents have been shown to inhibit ca2+-stimulated enzymes such as phosphorylase kinase and myosin light chain kinase in aortic smooth muscle, indicating that one major role of cgmp is to reduce the levels of free intracellular ca2+. | [in vitro]
the effects of rp-8-bromo-cyclic gmps on intracellular calcium concentrations in cultured rat aortic smooth muscle cells were studied. results showed that both angiotensin ii and depolarizing concentrations of k+ were ableo to stimulate ca2+' accumulation in the cytoplasm. the increase in ca2+ because of angiotensin ii was associated with an increase in inositol phosphates, while that due to k+ was not. preincubation of cells with rp-8-bromo-cyclic gmps at 100 μm could cause an inhibition of peak ca2+ accumulation to either angiotensin ii or k+ [1]. another study found that like 8-bromo-cgmp, rp-8-bromo-cyclic gmps was also resistant to hydrolysis by phosphodiesterases. this rp isomer could bind cgk without activating it, leading to the competitive inhibition [2]. | [References]
[1] rashatwar, s. s.,cornwell, t.l. and lincoln, t.m. effects of 8-bromo-cgmp on ca2+ levels in vascular smooth muscle cells: possible regulation of ca2+-atpase by cgmp-dependent protein kinase. proceedings of the national academy of sciences of the united states of america 84(16), 5685-5689 (1987).
[2] butt, e. ,phler, d.,genieser, h.g., et al. inhibition of cyclic gmp-dependent protein kinase-mediated effects by (rp)-8-bromo-pet-cyclic gmps. british journal of pharmacology 116, 3110-3116 (1995). |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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