| Identification | Back Directory | [Name]
2H-1,2,4-Oxadiazine, 5-(4-chlorophenyl)-6-cyclopropyl-5,6-dihydro-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-, (5R,6S)-rel-(+)- | [CAS]
2085780-87-4 | [Synonyms]
FRM-024
2H-1,2,4-Oxadiazine, 5-(4-chlorophenyl)-6-cyclopropyl-5,6-dihydro-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-, (5R,6S)-rel-(+)- | [Molecular Formula]
C22H22ClN5O2 | [MOL File]
2085780-87-4.mol | [Molecular Weight]
423.9 |
| Chemical Properties | Back Directory | [Boiling point ]
595.8±60.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.83±0.61(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease. | [References]
[1] Bursavich MG, et al. Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator. J Med Chem. 2021 Oct 14;64(19):14426-14447. DOI:10.1021/acs.jmedchem.1c00904 |
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