| Identification | Back Directory | [Name]
Selective PI3Kδ Inhibitor 1 | [CAS]
2088525-31-7 | [Synonyms]
PI3Kδ-IN-7n
compound 7n
PI3K delta-IN-7n
Selective PI3Kδ Inhibitor 1
SelectivePI3KδInhibitor1(compound7n)
SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro- | [Molecular Formula]
C23H20FN7O | [MOL File]
2088525-31-7.mol | [Molecular Weight]
429.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble | [form ]
Solid | [color ]
Off-white to gray | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
PI3Kδ-IN-5 (compound 7n) is a highly potent and selective inhibitor of PI3Kδ with an IC50 of 0.9 nM[1]. | [Biological Activity]
Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively. | [in vivo]
Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively . | [target]
| Target | Value | PI3Kδ
(Cell-free assay) | 0.9 nM |
| [storage]
Store at -20°C | [References]
[1] Terstiege I, et al. Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors. Bioorg Med Chem Lett. 2017;27(3):679-687. DOI:10.1016/j.bmcl.2016.11.004 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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