| Identification | Back Directory | [Name]
YM-60828 (MsOH salt) | [CAS]
209187-02-0 | [Synonyms]
YM 466
YM-466
YM75466
YM-75466
YM 75466
YM-75466 Free
YM-60828 (MsOH salt)
YRIFGKTUAWTSFP-UHFFFAOYSA-N | [Molecular Formula]
C28H35N5O8S2 | [MDL Number]
MFCD16038925 | [MOL File]
209187-02-0.mol | [Molecular Weight]
633.736 |
| Hazard Information | Back Directory | [Description]
YM-75466 is a factor Xa inhibitor potentially for the treatment of thrombosis. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner. YM-75466 exerted anti-FXa activity but not anti-thrombin activity. YM-75466, unlike heparin, exerts its antithrombotic effect through specific inhibition of FXa without any effect on thrombin. | [Uses]
YM-60828 is an FXa inhibitor with antithrombotic properties. In the rat arteriovenous shunt model, YM-60828 does not prolong coagulation time but reduces the levels of thrombin-antithrombin III complex (TAT) in a dose-dependent manner. YM-60828 exhibits only anti-FXa activity and does not show anti-thrombin activity, indicating that its antithrombotic effect is independent of thrombin. Therefore, the antithrombotic effect of YM-60828 can be monitored by TAT[1]. | [References]
[1] Sato K, et al. Relationship between the antithrombotic effect of YM-75466, a novel factor Xa inhibitor, and coagulation parameters in rats. Eur J Pharmacol. 1998 Apr 24;347(2-3):231-6. DOI:10.1016/s0014-2999(98)00101-0 |
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