| Identification | Back Directory | [Name]
Glutaminyl Cyclase Inhibitor 3 | [CAS]
2092921-50-9 | [Synonyms]
Glutaminyl Cyclase Inhibitor 3 | [Molecular Formula]
C24H32N6O2S | [MDL Number]
MFCD32174243 | [MOL File]
2092921-50-9.mol | [Molecular Weight]
468.61 |
| Chemical Properties | Back Directory | [Boiling point ]
706.7±70.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.35±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer's compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1].
IC50: 4.5 nM (hGC)[1]. | [Uses]
Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions[1]. | [storage]
Store at -20°C | [References]
[1]. Hoang VH, et al. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590. |
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