| Identification | Back Directory | [Name]
N-(Azido-PEG2)-N-Boc-PEG3-t-butyl ester | [CAS]
2093153-07-0 | [Synonyms]
YUN 53070
N-(Azido-PEG2)-N-Boc-PEG3-Boc
N-(Azido-PEG2)-N-Boc-PEG3-t-butyl este
N-(Azido-PEG2)-N-Boc-PEG3-t-butyl ester | [Molecular Formula]
C24H46N4O9 | [MDL Number]
MFCD30723282 | [MOL File]
2093153-07-0.mol | [Molecular Weight]
534.643 |
| Hazard Information | Back Directory | [Description]
N-(Azido-PEG2)-N-Boc-PEG3-t-butyl ester is a branched PEG molecule with a terminal azide group, Boc protected amine, and a terminal t-butyl ester. The azide group enables Click Chemistry. The Boc protected amine can be deprotected under acidic conditions, and the t-butyl protected carboxyl group can be hydrolyzed nder mild acidic conditions. | [Uses]
N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG2)-N-Boc-PEG3-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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