| Identification | Back Directory | [Name]
N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester | [CAS]
2112731-94-7 | [Synonyms]
N-(Azido-PEG3)-N-Boc-PEG4-Boc
N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester | [Molecular Formula]
C28H54N4O11 | [MDL Number]
MFCD30723227 | [MOL File]
2112731-94-7.mol | [Molecular Weight]
622.749 |
| Hazard Information | Back Directory | [Description]
N-(Azido-PEG3)-N-Boc-PEG4-t-butyl ester is a branched molecule with a terminal azide group and a t-butyl ester group. Azide (N3) enables PEGylation via Click Chemistry. Boc group and the t-butyl protected carboxyl group can be deprotected under mild acidic conditions. | [Uses]
N-(Azido-PEG3)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-Boc-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|